ARTIFICIAL INTELLIGENCE ASSESSMENT OF THE POTENTIAL OF TOCILIZUMAB ALONG WITH CORTICOSTEROIDS THERAPY FOR THE MANAGEMENT OF COVID-19 EVOKED ACUTE RESPIRATORY DISTRESS SYNDROME.

Artificial intelligence assessment of the potential of tocilizumab along with corticosteroids therapy for the management of COVID-19 evoked acute respiratory distress syndrome.

Acute respiratory distress syndrome (ARDS), associated with high mortality rate, affects up to Dugouts 67% of hospitalized COVID-19 patients.Early evidence indicated that the pathogenesis of COVID-19 evoked ARDS is, at least partially, mediated by hyperinflammatory cytokine storm in which interleukin 6 (IL-6) plays an essential role.The corticoster

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Revealing the mechanisms of protein disorder and N-glycosylation in CD44-hyaluronan binding using molecular simulation

The extracellular N-terminal hyaluronan binding domain (HABD) of CD44 is a small globular domain that confers hyaluronan (HA) binding functionality to this large transmembrane glycoprotein.When recombinantly expressed by itself, HABD exists as a globular water-soluble protein that retains the Wooden Kit capacity to bind HA.This has enabled atomic-r

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Evaluating the Impact of a Targeted Approach Designed to Build Executive Function Skills: A Randomized Trial of Brain Games

This paper reports results from an impact study of Brain Games (BGs), a classroom-based intervention designed to build preschool and school-aged children’s executive functions (EFs) and related self-regulation skills.The study employed a classroom-randomized, experimental design with 626 students in 36 pre-K through fourth grade classrooms in cha

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